Pastor John, but now have shipwrecked it, we must conclude that one can lose true faith in Christ.

How would you respond to this claim? Is there more that can be said about these two men, besides, “Since other Scriptures teach perseverance, then we must assume that the faith of Hymenaeus and Alexander must have been a mere profession”?

I think the last sentence in your question does indeed go a long way towards answering your own question, though I believe much more could and should be said.

The 1 Timothy 1:18-20 passage reads:

This charge I entrust to you, Timothy, my child, in accordance with the prophecies previously made about you, that by them you may wage the good warfare, holding faith and a good conscience. By rejecting this, some have made shipwreck of their faith, among whom are Hymenaeus and Alexander, whom I have handed over to Satan that they may learn not to blaspheme.

To fully exegete the passage would take far more space than a short blog article would allow for, but I would like to draw out a number of points from the biblical text.
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