The Discovery Institute identifies five areas of science that pose serious problems for neo-Darwinianism:

1. Genetics – Mutations cause harm and do not build complexity.
2. Biochemistry – Unguided and random processes cannot produce cellular complexity.
3. Paleontology – The fossil record lacks intermediate fossils.
4. Taxonomy – Biologists have failed to construct Darwin’s “Tree of Life.”
5. Chemistry – The chemical origin of life remains an unsolved mystery.